Wednesday, November 12, 2008

SIRIUS II trial suggests ularitide holds potential as new treatment for acute decompensated congestive heart failure




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"Results of the SIRIUS II study floor show ularitide to be well-tolerated and designate orderly stale, dose-dependent favorable hemodynamic effects and improvements in cardiac harvest and dyspnea or conciseness of breath. Kidney activate be also potted during the three year watch interval subsequently fame with ularitide," said Veselin Mitrovic, M.D., Medical Director of the Research Unit/Kerckhoff Clinic, Bad Nauheim. "Based on the cooperative findings, ularitide clasp central promise to address unmet wants in admin of ADHF." The SIRIUS II accomplishment was a randomized, double-blind, placebo-controlled clinical trial conduct at 19 centre in Europe. Primary endpoints in the study were swing in pulmonary capillary congest trauma (PCWP) and change in dyspnea chalk up, both at six hours. A whole of 221 patients were randomized commonly to receive ularitide 7.5, 15, or 30 ng/kg/min given intravenously in place of a 24-hour infusion, or placebo.



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